Which of the following statements supports the one gene-one enzyme hypothesis?A) A mutation in a single gene can result in a defective protein.B) Alkaptonuria results when individuals lack multiple enzymes involved in the catalysis of homogentisic acid.C) Sickle-cell anemia results in normal hemoglobin.D) Multiple antibody genes can code for different related proteins, depending on the splicing that takes place post-transcriptionally.